The Ooze for the Sega Genesis is a unique action-puzzle game where players control a sentient green ooze named Dr. Caine, a scientist transformed into a living slime after uncovering a sinister corporate plot. Players navigate hazardous levels by slithering through pipes, toxic waste, and enemy-infested areas while attacking foes by spitting globules of ooze or extending their body. The game features a strategic element, as losing too much mass leaves the player vulnerable, but absorbing enemies and toxic waste helps regenerate size.